OGG1 anticorps (CF®740)

N° du produit ABIN7649057

L’anticorps Souris Monoclonal anti-OGG1 a été validé pour IHC et IHC (fp). Il convient pour détecter OGG1 dans des échantillons de Humain.

Aperçu rapide pour OGG1 anticorps (CF®740) (ABIN7649057)

Antigène: OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp OGG1 est conjugé à/à la CF®740

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: CPTC-OGG1-1

Détail du produit anti-OGG1 anticorps (CF®740)

Fonction: 8-Oxoguanine DNA Glycosylase(CPTC-OGG1-1), CF740 conjugate

Attributs du produit: 8-Oxoguanine DNA Glycosylase (OGG1), otherwise known as N-Glycosylase/DNA lyase, is the enzyme responsible for the excision of 8-oxoguanine (8-oxoG), a mutagenic base by-product which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Accumulation of 8-oxoG increases the occurrence of A:T to C:G or G:C to T:A transversion mutations, because 8-oxoG forms a stable basepair with adenine as well as with cytosine. The OGG1 gene encodes eight isoforms (OGG1A-C, OGG2A-E) which result from alternative splicing of a single messenger RNA. The OGG1A splice variant is the most prevalent form and localizes to the nucleus, whereas the OGG2A splice variant is targeted to the mitochondria. Defects in OGG1 may be a cause of renal cell carcinoma. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Recombinant full-length human OGG1 protein

Isotype: IgG2c, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Positive Control: HeLa or Jurkat cells. Kidney, skin or lymph node.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % rBSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur OGG1

Antigène: OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))

Autre désignation: N-Glycosylase/DNA lyase

Sujet:

Synonyms: 8-oxoguanine DNA glycosylase, HMMH, HOGG1, MUTM, OGH1

Gene Symbol: OGG1

Poids moléculaire: 39 kDa

ID gène: 4968

UniProt: O15527

Pathways: Réparation de l'ADN