Cathepsin D anticorps (AA 104-250) (CF®594)

N° du produit ABIN7650676

Cet anticorps Souris Monoclonal détecte spécifiquement Cathepsin D dans WB, IHC et IHC (fp). Il présente une réactivité envers Humain.

Aperçu rapide pour Cathepsin D anticorps (AA 104-250) (CF®594) (ABIN7650676)

Antigène: Cathepsin D (CTSD)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Cathepsin D est conjugé à/à la CF®594

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: CTSD-3082

Détail du produit anti-Cathepsin D anticorps (CF®594)

Épitope: AA 104-250

Fonction: Cathepsin D (Tumor Marker)(CTSD/3082), CF594 conjugate

Attributs du produit: Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 43 kDa preprocathepsin D that is cleaved and glycosylated to form a 46 kDa procathepsin D and then further cleaved to produce 28 kDa and 15 kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimer's disease. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Recombinant fragment of human Cathepsin D protein (around aa 104-250)

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Positive Control: K-562, A431 or SK-BR3 cells. Kidney, Liver, Lung or Breast.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur Cathepsin D

Antigène: Cathepsin D (CTSD)

Autre désignation: Cathepsin D

Sujet:

Synonyms: Cathepsin D, CTSD, Lysosomal aspartyl peptidase

Gene Symbol: CTSD

Poids moléculaire: 46 kDa (Procathepsin D), 28 kDa (Cathepsin D)

ID gène: 1509

UniProt: P07339

Pathways: Peptide Hormone Metabolism