Dystrophin anticorps (AA 114-263)

N° du produit ABIN7653344

L’anticorps Souris Monoclonal anti-Dystrophin a été validé pour IHC et IHC (fp). Il convient pour détecter Dystrophin dans des échantillons de Humain.

Aperçu rapide pour Dystrophin anticorps (AA 114-263) (ABIN7653344)

Antigène: Dystrophin (DMD)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Dystrophin est non-conjugé

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: DMD-3241

Détail du produit anti-Dystrophin anticorps

Épitope: AA 114-263

Fonction: Dystrophin (DMD) (Marker of Duchenne and Becker Muscular Dystrophy)(DMD/3241)

Attributs du produit: Dystrophin-glycoprotein complex (DGC) connects the F-Actin cytoskeleton on the inner surface of muscle fibers to the surrounding extracellular matrix, through the cell membrane interface. A deficiency in this protein contributes to Duchenne (DMD) and Becker (BMD) muscular dystrophies. The human dystrophin gene measures 2. 4 megabases, has more than 80 exons, produces a 14 kb mRNA and contains at least 8 independent tissue-specific promoters and 2 poly A sites. The dystrophin mRNA can undergo differential splicing and produce a range of transcripts that encode a large set of proteins. Dystrophin represents approximately 0. 002 % of total striated muscle protein and localizes to triadic junctions in skeletal muscle, where it is thought to influence calcium ion homeostasis and force transmission. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: A recombinant fragment (around aa 114-263) of human DMD protein

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Positive Control: Human skeletal muscle and heart muscle tissues (IHC).

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: PBS, 0.05 % BSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur Dystrophin

Antigène: Dystrophin (DMD)

Autre désignation: Dystrophin

Sujet:

Synonyms: BMD, CMD3B, Duchenne muscular dystrophy (DMD), Dystrophin, Muscular dystrophy Duchenne and Becker types

Gene Symbol: DMD

Tissue Expression: Muscle

Poids moléculaire: 427 kDa

ID gène: 1756

UniProt: P11532

Pathways: Skeletal Muscle Fiber Development