PAX2A anticorps (AA 223-354) (Biotin)

N° du produit ABIN7658386

Cet anticorps Souris Monoclonal détecte spécifiquement PAX2A dans IHC et IHC (fp). Il présente une réactivité envers Humain.

Aperçu rapide pour PAX2A anticorps (AA 223-354) (Biotin) (ABIN7658386)

Antigène: PAX2A (Paired Box Gene 2a (PAX2A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PAX2A est conjugé à/à la Biotin

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: PAX2-1104

Détail du produit anti-PAX2A anticorps (Biotin)

Épitope: AA 223-354

Fonction: PAX2 (Renal Cell & Ovarian Carcinoma Marker) (PAX2/1104), Biotin conjugate

Attributs du produit: This antibody recognizes a protein of 42 kDa, which is identified as PAX2. It is a member of the paired box family of transcription factors, which is required for development and proliferation of the kidney, brain, and MA1/4llerian organs. PAX2 genes contain a highly conserved DNA sequence within the paired box region, which encodes a DNA-binding domain, enabling PAX proteins to bind the promoters of specific genes to transcriptionally regulate their expression. PAX2 is specifically expressed in the developing central nervous system, eye, ear, and urogenital tract, and is essential for the development of these organs. In normal adult tissues PAX2 was mainly detected in the urogenital system, including kidney, ureteric epithelium, fallopian tube epithelium, ovary and uterus. In tumors, PAX2 has been detected in renal cell carcinomas, Wilms' tumors, nephrogenic adenomas and papillary serous carcinoma of the ovary. PAX2 has been used as a marker for the identification of renal cell carcinoma and ovarian carcinoma by immunohistochemistry. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Recombinant fragment (around aa 223-354) human PAX2 protein

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Positive Control: NAMALWA cells. Fetal kidney or Renal Cell Carcinoma (RCC) or Ovarian Carcinoma.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur PAX2A

Antigène: PAX2A (Paired Box Gene 2a (PAX2A))

Autre désignation: PAX2

Sujet:

Synonyms: Paired box gene 2, paired box homeotic gene 2, paired box protein 2, Paired box protein Pax-2, Paired box protein Pax2

Gene Symbol: PAX2

Tissue Expression: Uterus|Kidney|Ovary

Poids moléculaire: 42 kDa

ID gène: 5076

UniProt: Q02962

Pathways: Carbohydrate Homeostasis, Stem Cell Maintenance, Tube Formation