ERCC2 anticorps

N° du produit ABIN7673032

Cet anticorps anti-ERCC2 Polyclonal Lapin (ABIN7673032) détecte spécifiquement ERCC2 dans WB et ELISA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour ERCC2 anticorps (ABIN7673032)

Antigène: ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERCC2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-ERCC2 anticorps

Fonction: ERCC2 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: excision repair cross-complementing rodent repair deficiency, complementation group 2

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur ERCC2

Antigène: ERCC2 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2))

Autre désignation: ERCC2

Sujet:

Synonyms: General transcription and DNA repair factor IIH helicase subunit XPD (TFIIH subunit XPD)|Basic transcription factor 2 80 kDa subunit (BTF2 p80)|CXPD|DNA excision repair protein ERCC-2|DNA repair protein complementing XP-D cells|TFIIH basal transcription factor complex 80 kDa subunit (TFIIH 80 kDa subunit, TFIIH p80)|Xeroderma pigmentosum group D-complementing protein|ERCC2|XPD|XPDC

Background: ATP-dependent 5'-3' DNA helicase, component of the core-TFIIH basal transcription factor. Involved in nucleotide excision repair(NER) of DNA by opening DNA around the damage, and in RNA transcription by RNA polymerase II by anchoring the CDK-activating kinase(CAK) complex, composed of CDK7, cyclin H and MAT1, to the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.

Poids moléculaire: 80 kDa

ID gène: 2068

UniProt: P18074

Pathways: Réparation de l'ADN