PD-L1 anticorps (PerCP-Cy5.5)

N° du produit ABIN7674245

Cet anticorps Souris Monoclonal détecte spécifiquement PD-L1 dans FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour PD-L1 anticorps (PerCP-Cy5.5) (ABIN7674245)

Antigène: PD-L1 (CD274 (PD-L1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PD-L1 est conjugé à/à la PerCP-Cy5.5

Application: Flow Cytometry (FACS)

Clone: 29E-2A3

Détail du produit anti-PD-L1 anticorps (PerCP-Cy5.5)

Fonction: PerCP-Cy5.5 Anti-Human CD274/PD-L1 Antibody

Purification: 0

Pureté: 0

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Volume per test: 5μL. Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0. 1 % sodium azide, 1 % BSA, pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: 4 °C

Stockage commentaire: 2-8°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur PD-L1

Antigène: PD-L1 (CD274 (PD-L1))

Autre désignation: CD274

Sujet:

Synonyms: B7H1PD-L1PDCD1L1PDCD1LG1PDL1|B7 homolog 1|B7-H|B7-H1|Programmed cell death ligand 1

Background: CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

Poids moléculaire: 0

ID gène: 29126

UniProt: Q9NZQ7

Pathways: Cancer Immune Checkpoints