TARDBP anticorps

N° du produit ABIN7674407

Cet anticorps Lapin Polyclonal détecte spécifiquement TARDBP dans WB et ELISA. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour TARDBP anticorps (ABIN7674407)

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TARDBP est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-TARDBP anticorps

Fonction: phospho-TDP43 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: TAR DNA binding protein

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur TARDBP

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Autre désignation: TDP43

Sujet:

Synonyms: TAR DNA-binding protein 43 (TDP-43)|TARDBP|TDP43

Background: TDP-43 is a 414 amino acid (aa) nuclear DNA and RNA-binding protein which regulates transcription and splicing. TDP-43 is aberrantly expressed in most forms of amylotrophic lateral sclerosis and frontotemporal lobar degeneration. In these cases it is absent from the nucleus and accumulates, along with a truncated 25 kDa form, in ubiquitin-containing inclusion bodies. In pathological tissues, TDP-43 is highly phosphorylated and Ser409/410 is the main phosphorylation site. Among the TDP-43 protein fragments, the 25 kDa fragment is also highly phosphorylated and widely believed to be pathogenic. This antibody is a rabbit polyclonal antibody recognizing TDP-43 only when phosphorylated at 409/410. This antibody detects phosphorylated forms of TDP-43 as well as the cleavage product of 25 kDa.

Poids moléculaire: 48 kDa

ID gène: 23435

UniProt: Q13148

Pathways: Positive Regulation of Peptide Hormone Secretion