VEGFR2/CD309 anticorps (pTyr1175)

N° du produit ABIN7674409

Cet anticorps anti-VEGFR2/CD309 est un anticorps Lapin Polyclonal détectant VEGFR2/CD309 dans WB, IHC et ELISA. Adapté pour Humain, Souris et Rat.

Aperçu rapide pour VEGFR2/CD309 anticorps (pTyr1175) (ABIN7674409)

Antigène: VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VEGFR2/CD309 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-VEGFR2/CD309 anticorps

Épitope: pTyr1175

Fonction: Phospho-VEGF Receptor 2 antibody

Purification: Immunogen affinity purified

Pureté: ≥95 % as determined by SDS-PAGE

Immunogène: A phospho specific peptide corresponding to residues surrounding Y1175 of human VEGF Receptor 2

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500 - 1:1000, IHC: 1:50 - 1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze / thaw cycles.

Stock: -20 °C

Stockage commentaire: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Date de péremption: 12 months

Détails sur VEGFR2/CD309

Antigène: VEGFR2/CD309 (VEGFR2) (VEGF Receptor 2 (VEGFR2))

Autre désignation: VEGF Receptor 2

Sujet:

Synonyms: Vascular endothelial growth factor receptor 2 (VEGFR-2)|Fetal liver kinase 1 (FLK-1)|Kinase insert domain receptor (KDR)|Protein-tyrosine kinase receptor flk-1|KDR|FLK1|VEGFR2

Background: KDR, also named as VEGFR-2, FLK1 and CD309, is a receptor for VEGF or VEGFC. KDR which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. KDR functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.

Poids moléculaire: 250 kDa

ID gène: 3791

UniProt: P35968

Pathways: Signalisation RTK, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling