MYD88 anticorps (AA 201-296) (FITC)
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- Antigène Voir toutes MYD88 Anticorps
- MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))
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Épitope
- AA 201-296
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Reactivité
- Humain, Souris, Rat, Poulet
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp MYD88 est conjugé à/à la FITC
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Poulet, Humain, Souris, Rat
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from mouse MyD88
- Isotype
- IgG
- Top Product
- Discover our top product MYD88 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- MYD88 (Myeloid Differentiation Primary Response Gene (88) (MYD88))
- Autre désignation
- MyD88 (MYD88 Produits)
- Synonymes
- anticorps MYD88D, anticorps XMyD88, anticorps myd88d, anticorps MGC84928, anticorps CG2078, anticorps DMMYD88, anticorps DmMyD88, anticorps DmMyd88, anticorps Dmel\\CG2078, anticorps EP(2)2535, anticorps Kra, anticorps LD20892, anticorps MYD88, anticorps MyD88, anticorps Myd88F, anticorps dMyD88, anticorps dMyd88, anticorps kra, anticorps myd88, anticorps zgc:103541, anticorps GB12344, anticorps NV10640, anticorps myd88-a, anticorps myd88-b, anticorps myeloid differentiation primary response 88, anticorps myeloid differentiation primary response 88 S homeolog, anticorps myeloid differentiation primary response gene 88, anticorps CG2078 gene product from transcript CG2078-RB, anticorps myeloid differentiation primary response protein MyD88-A, anticorps myeloid differentiation primary response protein MyD88, anticorps myeloid differentiation factor 88, anticorps myeloid differentiation primary response 88 L homeolog, anticorps MYD88, anticorps myd88.S, anticorps Myd88, anticorps myd88, anticorps LOC413194, anticorps LOC100118553, anticorps LOC575153, anticorps myd88.L
- Sujet
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Synonyms: Myeloid differentiation primary response protein MyD88, Myd88
Background: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Isoform 2 is defective in its ability to induce IRAK phosphorylation and NF-kappa-B activation and can function as a negative regulator of activation by IL-1 or lipopolysaccharide (LPS). Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.
- ID gène
- 17874
- UniProt
- P22366
- Pathways
- Signalisation NF-kappaB, Signalisation TLR, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades
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