Recombinant ErbB2/Her2 anticorps

N° du produit ABIN7795221

L’anticorps anti-ErbB2/Her2 Monoclonal Humanized est utilisé pour la détection de ErbB2/Her2 dans des échantillons de Humain. Il a été validé pour ELISA, Func, IGA et Neut.

Aperçu rapide pour Recombinant ErbB2/Her2 anticorps (ABIN7795221)

Antigène: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Humanized

Clonalité: Monoclonal

Conjugué: Cet anticorp ErbB2/Her2 est non-conjugé

Application: ELISA, Functional Studies (Func), Immunogenicity Assay (IGA), Neutralization (Neut)

Classe de qualité: In vivo Grade

Clone: 4D5 (muMAb)

Détail du produit anti-ErbB2/Her2 anticorps

Expression System: Mammalian cells

Fonction: In vivo Grade Recombinant Anti-Human HER2/ErbB-2/c-neu monoclonal Antibody, Mouse IgG1 Kappa

Attributs du produit: Trastuzumab, a humanized monoclonal antibody (clone HuMAb 4D5-8), interferes with the HER2/neu receptor and is mainly used to treat certain breast cancers, especially HER2-positive metastatic breast cancer. Combined with chemotherapy, trastuzumab increases both survival and response rate. There are four closely related receptor tyrosine kinases in the ErbB family of receptors: EGFR (ErbB-1, HER1 in humans), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Bound by members of the epidermal growth factor family (EGF-family) of extracellular protein ligands, the HER receptors embedded in the cell membrane promote cell growth and division by turning genes on and off. The HER2 pathway stimulates cell proliferation if it normally functions, when HER2 is overexpressed, cell growth accelerates beyond its normal limits, which happens in some cancers, notably certain types of breast cancer.

Purification: Protein A or G affinity column

Pureté: >95 % by reducing SDS-PAGE

niveau d'endotoxine: < 1 EU per 1 mg of the protein by the LAL method

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: > 3 mg/mL

Stock: 4 °C,-20 °C

Stockage commentaire: Short time 2 to 8°C as supplied. Long time -20°C to -70°C as supplied.

Détails sur ErbB2/Her2

Antigène: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Autre désignation: HER2

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development