Cyclin D2 anticorps (AA 161-288) (Cy5)

N° du produit ABIN738370

Cet anticorps Lapin Polyclonal détecte spécifiquement Cyclin D2 dans WB, FACS, IF (cc) et IF (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Cyclin D2 anticorps (AA 161-288) (Cy5) (ABIN738370)

Antigène: Cyclin D2 (CCND2)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cyclin D2 est conjugé à/à la Cy5

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-Cyclin D2 anticorps (Cy5)

Épitope: AA 161-288

Fonction: Cyclin D2 Polyclonal Antibody, Cy5 Conjugated

Réactivité croisée: Humain, Rat

Homologie: Mouse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Cyclin D2

Isotype: IgG

Information d'application

Indications d'application: WB(1:300-5000), FCM(1:20-100), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200), IF(ICC)(1:50-200)

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur Cyclin D2

Antigène: Cyclin D2 (CCND2)

Autre désignation: Cyclin D2

Sujet:

Synonyms: MPPH3, KIAK2, G1/S-specific cyclin-D2, CCND2

Background: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

ID gène: 894

UniProt: P30279

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases