Recombinant CD3D anticorps

N° du produit ABIN7828082

L’anticorps anti-CD3D Monoclonal Lapin est utilisé pour la détection de CD3D dans des échantillons de Humain. Il a été validé pour WB, IHC, IP, FACS et IF.

Aperçu rapide pour Recombinant CD3D anticorps (ABIN7828082)

Antigène: CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CD3D est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: A525

Détail du produit anti-CD3D anticorps

Fonction: Recombinant CD3D Monoclonal Antibody

Purification: Protein A purified

Immunogène: Recombinant human CD3D fragment

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:2000-1:10000,IHC 1:200-1:1000,IF 1:50-1:200,FCM 1:50-1:100,IP 1:25-1:50

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur CD3D

Antigène: CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))

Autre désignation: CD3D

Sujet: IMD,CD3D,CD3-DELTA,IMD19,T3D,T-Cell Receptor T3 Delta Chain,T-cell surface glycoprotein CD3 delta chain,T3,CD3 delta,CD3D is a component of the TCR-CD3 complex, which is present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition, CD3D plays an essential role in thymocyte differentiation. It participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. It interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 19 kDa

Observed MW: 23 kDa The actual band is not consistent with the expectation.

UniProt: P04234

Pathways: TCR Signaling, CXCR4-mediated Signaling Events