Recombinant MAP2K5 anticorps

N° du produit ABIN7828398

Cet anticorps anti-MAP2K5 Monoclonal Lapin (Clone A623) (ABIN7828398) détecte spécifiquement MAP2K5 dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant MAP2K5 anticorps (ABIN7828398)

Antigène: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp MAP2K5 est non-conjugé

Application: Western Blotting (WB)

Clone: A623

Détail du produit anti-MAP2K5 anticorps

Fonction: Recombinant MEK5 Monoclonal Antibody

Purification: Protein A purified

Immunogène: Recombinant human MEK5 fragment

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:1000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur MAP2K5

Antigène: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Autre désignation: MEK5

Sujet: MEK,MKK,MAP2K,MAPKK,PRKMK,MAP2K5,HsT17454,MAPKK5,MEK5,PRKMK5,MKK5,Dual specificity mitogen activated protein kinase kinase 5,Dual specificity mitogen-activated protein kinase kinase 5,EC 2.7.12.2,kinase 5,MAP kinase kinase 5,MAP kinase kinase MEK5b,MAPK/ERK kinase 5,MAPKK 5,MEK 5,mitogen-activated,mitogen-activated protein kinase kinase 5,MP2K5,Protein kinase,SAPKK5,SKK5,MEK5 is a dual specific kinase that specifically activates ERK5 involved in the regulation of diverse cellular processes, including cell growth, survival, and differentiation. The MEK5-ERK5 pathway is activated in numerous cancer types and plays a role in tumor growth and metastasis. Pharmacological targeting of the MEK5-ERK5 pathway has been investigated as a strategy for cancer treatment. MEK5 is activated by a variety of stimuli, including growth factors, cytokines, and oxidative stress. Activation of MEK5 is triggered by upstream kinases MEKK2 and MEKK3, leading to phosphorylation of MEK5 at Ser311 and Thr315, which subsequently leads to MEK5 dependent phosphorylation of EKR5 at Thr218 and Tyr220. Phosphorylation of ERK5 leads to nuclear translocation and regulation of several oncogenic transcription factors, including MEF2C, c-Fos, c-Myc, and Sap1. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 49, 50 kDa

Observed MW: 49, 50 kDa

UniProt: Q13163

Pathways: Signalisation MAPK, Neurotrophin Signaling Pathway