Recombinant SOCS3 anticorps

N° du produit ABIN7828595

L’anticorps anti-SOCS3 Monoclonal Lapin est utilisé pour la détection de SOCS3 dans des échantillons de Souris. Il a été validé pour WB.

Aperçu rapide pour Recombinant SOCS3 anticorps (ABIN7828595)

Antigène: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Type d'anticorp: Recombinant Antibody

Reactivité: Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp SOCS3 est non-conjugé

Application: Western Blotting (WB)

Clone: A723

Détail du produit anti-SOCS3 anticorps

Fonction: Recombinant SOCS3 Monoclonal Antibody

Purification: Protein A purified

Isotype: IgG, kappa

Information d'application

Indications d'application: WB 1:1000-1:2000

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Date de péremption: 12 months

Détails sur SOCS3

Antigène: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Autre désignation: SOCS3

Sujet: CIS,ATOD,Cish,SSI,SOCS3,ATOD4,CIS3,Cish3,SOCS-3,SSI-3,SSI3,MGC71791,The suppressor of cytokine signaling (SOCS) family members are negative regulators of cytokine signal transduction that inhibit the Jak/Stat pathway. The SOCS family consists of at least 8 members including the originally identified cytokine-inducible SH2-containing protein (CIS1), as well as SOCS1-7. Each SOCS family member contains a central SH2 domain and a conserved carboxy-terminal motif designated as the SOCS box. These proteins are important regulators of cytokine signaling, proliferation, differentiation, and immune responses. Low levels of SOCS3 are observed in lung, spleen, and thymus and, like other SOCS family members, its expression is rapidly induced by a number of factors including interleukins, EPO, IFN-γ, CSF, and TNF-α. SOCS3 uses its SH2 domain to bind activated Jaks and their cognate receptors to provide negative feedback inhibition. In addition to the initially described inducers of SOCS3 expression, subsequent studies have described SOCS3-mediated negative feedback inhibition for leptin, GH, chemokine receptors, insulin, and certain pathogens. SOCS3 deletion results in embryonic lethality with placental insufficiency. SOCS3 signaling has been linked pathologically to allergic responses, inflammatory disease, endotoxic shock, wound repair, and obesity. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Poids moléculaire:

Calculated MW: 25 kDa

Observed MW: 25, 15 kDa The actual band is not consistent with the expectation.

UniProt: O14543

Pathways: Signalistation JAK/STAT, Response to Growth Hormone Stimulus, Hepatitis C