Recombinant NGFR anticorps (Extracellular Domain)

N° du produit ABIN7864369

L’anticorps anti-NGFR Monoclonal Lapin est utilisé pour la détection de NGFR dans des échantillons de Humain et Non-Human Primate. Il a été validé pour IHC.

Aperçu rapide pour Recombinant NGFR anticorps (Extracellular Domain) (ABIN7864369)

Antigène: NGFR (Nerve Growth Factor Receptor (NGFR))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Non-Human Primate

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp NGFR est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: NGFR-8590R

Détail du produit anti-NGFR anticorps

Épitope: Extracellular Domain

Expression System: HEK-293 Cells

Fonction: Recombinant NGF-Receptor (p75) / CD271 (Soft Tissue Tumor Marker) Antibody

Specificité: It recognizes a glycoprotein of 75 kDa, identified as low affinity Nerve Growth Factor (NGF) Receptor (p75NGFR) or Neurotrophin Receptor (p75NTR). NGFR is expressed in various neural crest cells and their tumors such as melanocytes, melanomas, neuroblastomas, pheochromocytomas and neurofibromas. Reportedly, anti-NGFR is a reliable marker for desmoplastic and neurotropic melanomas. NGFR is expressed in mature non-neural cells such as perivascular cells, dental pulp cells, lymphoidal follicular dendritic cells, basal epithelium of oral mucosa and hair follicles, prostate basal cells, and myoepithelial cells. Anti-NGFR stains the myoepithelial cells of breast ducts and intra-lobular fibroblasts of breast ducts.

Purification: 200ug/ml of Ab produced in HEK293 cell mammalian-based expression system.

Immunogène: Recombinant fragment of human p75 NGFR protein corresponding to the extracellular domain

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur NGFR

Antigène: NGFR (Nerve Growth Factor Receptor (NGFR))

Autre désignation: NGF-Receptor

Sujet:

CD271, Gp80-LNGFR, Low affinity nerve growth factor receptor, Low affinity neurotrophin receptor p75NTR,), p75 ICD, p75 Neurotrophin receptor, Tumor necrosis factor receptor superfamily member 16 (TNFRSF16)

Neuronal axons, Schwann cells, and perineural cells of peripheral nerves, or tumors of nerve sheath differentiation e.g. Schwannoma, Neurofibroma. Soma and axons of sensory neurons, and ganglionic satellite cells. Melanomas.

Poids moléculaire: 75kDa

ID gène: 4804

UniProt: P08138

Pathways: Signalisation NF-kappaB, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding