Recombinant Glypican 3 anticorps (AA 400-550)

N° du produit ABIN7864314

Cet anticorps Lapin Monoclonal détecte spécifiquement Glypican 3 dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant Glypican 3 anticorps (AA 400-550) (ABIN7864314)

Antigène: Glypican 3 (GPC3)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Glypican 3 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: GPC3-8148R

Détail du produit anti-Glypican 3 anticorps

Épitope: AA 400-550

Fonction: Recombinant Glypican-3 (GPC3) (Hepatocellular Carcinoma Marker) Antibody

Specificité: Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilm s tumor. In patients with HCC, GPC3 is overexpressed in neoplastic liver tissue and elevated in serum, but is undetectable in normal liver, benign liver, and the serum of healthy donors. GPC3 expression is also found to be higher in HCC liver tissue than in cirrhotic liver or liver with focal lesions such as dysplastic nodules and areas of hepatic adenoma (HA) with malignant transformation. In the context of testicular germ cell tumors, GPC3 expression is up regulated in certain histologic subtypes, specifically yolk sac tumors and choriocarcinoma. A high level of GPC3 expression is also found in some types of embryonal tumors, such as Wilm s tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100 % in follicular carcinoma and 70 % in papillary carcinoma. Expression of GPC3 in follicular carcinoma is significantly higher than that of follicular adenoma. In contrast, GPC3 is not expressed in anaplastic carcinoma.

Purification: 200ug/ml of Ab purified by Protein A Column.

Immunogène: Recombinant fragment (around aa400-550) of human GPC3 protein (exact sequence is proprietary)

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur Glypican 3

Antigène: Glypican 3 (GPC3)

Autre désignation: Glypican-3

Sujet:

DGSX, Glypican proteoglycan 3, GPC3, GTR2-2, Heparan sulphate proteoglycan, Intestinal protein OCI-5, MXR7, OCI-5, SDYS, Secreted glypican-3, SGBS1

Human placenta or hepatocellular carcinoma.

Poids moléculaire: 67kDa

ID gène: 2719, 644108

UniProt: P51654

Pathways: Glycosaminoglycan Metabolic Process