CD3D anticorps (AA 1-171)

N° du produit ABIN7863949

L’anticorps anti-CD3D Monoclonal Souris est utilisé pour la détection de CD3D dans des échantillons de Humain. Il a été validé pour WB et IHC.

Aperçu rapide pour CD3D anticorps (AA 1-171) (ABIN7863949)

Antigène: CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD3D est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: CD3D-8898

Détail du produit anti-CD3D anticorps

Épitope: AA 1-171

Fonction: CD3D / T Cell Receptor delta Antibody

Specificité: The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. Much of this signaling process can be attributed to a multisubunit complex of proteins that associates directly with the TCR. This complex has been designated CD3 (cluster of differentiation 3). It is composed of five invariant polypeptide chains that associate to form three dimers: a heterodimer of g and e chains (ge), a heterodimer of d and e chains (de) and a homodimer of two z chains (zz) or a heterodimer of z and h chains (zh). The z and h chains are encoded by the same gene but differ in their carboxyl-terminal ends due to an alternative splicing event. The g, e and d chains each contain a single copy of a conserved immunoreceptor tyrosine-based activation motif (ITAM). In contrast, the z chain contains three consecutive copies of the same motif. Phosphorylated ITAMs act as docking sites for protein kinases such as ZAP-70 and Syk and are also capable of regulating their kinase activity. The crystal structure of the ZAP-70 SH2 domains bound to the z chain ITAMs has been solved.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa1-171) of human CD3D protein (exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur CD3D

Antigène: CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))

Autre désignation: CD3D

Sujet:

CD3 antigen delta subunit, CD3 delta, CD3d antigen delta polypeptide (TiT3 complex), CD3d molecule delta (CD3-TCR complex), IMD19, OKT3 delta chain, T-cell receptor T3 delta chain, T-cell surface glycoprotein CD3 delta chain, T3D

Human peripheral blood. Jurkat cells. Tonsil or lymph node. MOLT-4.

Poids moléculaire: 20kDa

ID gène: 915, 504048

UniProt: P04234

Pathways: TCR Signaling, CXCR4-mediated Signaling Events