CD3G anticorps (AA 1-182)

N° du produit ABIN7858316

Cet anticorps Souris Monoclonal détecte spécifiquement CD3G dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour CD3G anticorps (AA 1-182) (ABIN7858316)

Antigène: CD3G (CD3g Molecule, gamma (CD3-TCR Complex) (CD3G))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD3G est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: CD3G-8794

Détail du produit anti-CD3G anticorps

Épitope: AA 1-182

Fonction: CD3G / CD3beta1 / TCR beta Antibody

Specificité: The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. Much of this signaling process can be attributed to a multisubunit complex of proteins that associates directly with the TCR. This complex has been designated CD3 (cluster of differentiation 3). It is composed of five invariant polypeptide chains that associate to form three dimers: a heterodimer of g and e chains (ge), a heterodimer of d and e chains (de) and a homodimer of two z chains (zz) or a heterodimer of z and h chains (zh). The z and h chains are encoded by the same gene but differ in their carboxyl-terminal ends due to an alternative splicing event. The g, e and d chains each contain a single copy of a conserved immunoreceptor tyrosinebased activation motif (ITAM). In contrast, the z chain contains three consecutive copies of the same motif. Phosphorylated ITAMs act as docking sites for protein kinases such as ZAP-70 and Syk and are also capable of regulating their kinase activity. The crystal structure of the ZAP-70 SH2 domains bound to the z chain ITAMs has been solved.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa1-182) of human CD3G protein (exact sequence is proprietary)

Isotype: IgG2c, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur CD3G

Antigène: CD3G (CD3g Molecule, gamma (CD3-TCR Complex) (CD3G))

Autre désignation: CD3G

Sujet:

CD3g antigen gamma polypeptide (TiT3 complex), CD3g molecule gamma (CD3 TCR complex), T cell antigen receptor complex gamma subunit of T3, T-cell surface glycoprotein CD3 gamma chain, T3G

Human colon|tonsil or spleen.

Poids moléculaire: 18-28kDa

ID gène: 917, 2259

UniProt: P09693

Pathways: TCR Signaling, CXCR4-mediated Signaling Events