Caspase 7 anticorps (AA 1-200)

N° du produit ABIN7858378

Cet anticorps anti-Caspase 7 Monoclonal Souris (Clone CASP7-9052) (ABIN7858378) détecte spécifiquement Caspase 7 dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Caspase 7 anticorps (AA 1-200) (ABIN7858378)

Antigène: Caspase 7 (CASP7) (Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Caspase 7 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: CASP7-9052

Détail du produit anti-Caspase 7 anticorps

Épitope: AA 1-200

Fonction: CASP7 / Caspase-7 Antibody

Specificité: A unique family of Cysteine proteases has been described that differs in sequence, structure and substrate specificity from any previously described protease family. This family, CED-3/caspase-1, is comprised of caspase-1, caspase-2, caspase-3, caspase-4, caspase-6, caspase-7 (also designated Mch3, ICE-LAP3 or CMH-1), caspase-9 and caspase-10. CED-3/caspase-1 family members function as key components of the apoptotic machinery and act to destroy specific target proteins which are critical to cellular longevity. Poly(ADP-ribose) polymerase plays an integral role in surveying for DNA mutations and double strand breaks. Caspase-3, caspase-7 and caspase-9, but not caspase-1, have been shown to cleave the nuclear protein PARP into an apoptotic fragment. Caspase-6, but not caspase-3, has been shown to cleave the nuclear lamins which are critical to maintaining the integrity of the nuclear envelope and cellular morphology. Caspase-10 has been shown to activate caspase-3 and caspase-7 in response to apoptotic stimuli.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa1-200) of human CASP7 protein (exact sequence is proprietary)

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody w2ithout azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur Caspase 7

Antigène: Caspase 7 (CASP7) (Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7))

Autre désignation: CASP7

Sujet:

Apoptotic protease MCH3, Caspase 7 apoptosis related cysteine peptidase, Caspase-7 subunit p11, CMH1, ICE LAP3, ICE-like apoptotic protease 3, LICE2, MCH3

Heart|HL60 or Jurkat cells. Human liver|liver or kidney.|spleen

Poids moléculaire: 28-34kDa

ID gène: 840, 9216

UniProt: P55210

Pathways: Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity