Kallikrein 4 anticorps (AA 1-200)

N° du produit ABIN7858589

Cet anticorps Souris Monoclonal détecte spécifiquement Kallikrein 4 dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Kallikrein 4 anticorps (AA 1-200) (ABIN7858589)

Antigène: Kallikrein 4 (KLK4) (Kallikrein-Related Peptidase 4 (KLK4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Kallikrein 4 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: KLK4-8941

Détail du produit anti-Kallikrein 4 anticorps

Épitope: AA 1-200

Fonction: KLK4 / Kallikrein related peptidase 4 Antibody

Specificité: Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Human pancreatic/renal KLK encodes for the KLK1 enzyme, which is involved in post-translational processing of polypeptide precursors. The function of the other members of KLK gene family is still currently unknown, but evidence suggests that many KLKs are implicated in carcinogenesis. The human KLK gene family consists of 15 serine proteases. The human KLK genes are clustered on chromosome 19q13. Unlike other kalllikreins, the KLK4-15 encoded proteases are less related and do not contain a conventional KLK loop. Clusters of genes exhibit high prostatic (KLK2-4, KLK15) or pancreatic (KLK6-13) expression. KLK2 is also known as glandular kallikrein 2, tissue kallikrein, or HGK-1 and KLK3 is known as prostate-specific antigen (PSA). Both KLK2 and KLK3 have important applications in prostate cancer and breast cancer diagnostics. Many of the KLKs are regulated by steroid hormones and a few of them, specifically KLK3, KLK6 and KLK10, are known to be downregulated in breast and other cancers. KLK4 expression is abundant in skin, mammary gland and testis.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment of human KLK4 protein (around aa 1-200) (exact sequence is proprietary)

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Kallikrein 4

Antigène: Kallikrein 4 (KLK4) (Kallikrein-Related Peptidase 4 (KLK4))

Autre désignation: KLK4

Sujet:

7S nerve growth factor alpha chain, AI2A1, Alpha-NGF, Androgen-regulated message 1, ARM1, EC 3.4.21.-, EMSP1, Enamel Matrix Serine Protease 1, HK4, Kallikrein 4, Kallikrein L1, Kallikrein like protein 1, Kallikrein related-peptidase 4 (prostase, enamel matrix, prostate), KLK-L1, KLK4, Protease Serine 17, PRSS17, PSTS, Serine protease 17

Human skin tissue (IHC). MCF-7 cell lysates.

Poids moléculaire: 28-37kDa

ID gène: 9622, 218366

UniProt: Q9Y5K2

Pathways: Système du Complément