PKC iota anticorps (AA 100-300)

N° du produit ABIN7863285

Cet anticorps Souris Monoclonal détecte spécifiquement PKC iota dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour PKC iota anticorps (AA 100-300) (ABIN7863285)

Antigène: PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PKC iota est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: PRKCI-4912

Détail du produit anti-PKC iota anticorps

Épitope: AA 100-300

Fonction: Protein Kinase C iota / lambda / PRKCI Antibody

Specificité: Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions, including cell growth and differentiation, gene expression, hormone secretion and membrane function. PKCs were originally identified as serine/threonine protein kinases whose activity was dependent on calcium and phospholipids. Diacylglycerols (DAG) and tumor promoting phorbol esters bind to and activate PKC. PKCs can be subdivided into at least two major classes, including conventional (c) PKC isoforms (°™, æI, æII and Á) and novel (n) PKC isoforms ( 79oΩL, , 79oΩÊTO, , , l/i, m and n). Patterns of expression for each PKC isoform differ among tissues and PKC family members exhibit clear differences in their cofactor dependencies. For instance, the kinase activities of PKC 79oΩL and are independent of Ca2+. On the other hand, most of the other PKC members possess phorbol ester-binding activities and kinase activities.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa100-300) of human PRKCI protein (exact sequence is proprietary)

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur PKC iota

Antigène: PKC iota (PRKCI) (Protein Kinase C, iota (PRKCI))

Autre désignation: Protein Kinase C iota

Sujet:

aPKC lambda/iota, Atypical protein kinase C lambda/iota, Atypical protein kinase C-lambda/iota, nPKC-iota, nPKCiota, PKC lambda/iota, PKCI, PKCiota, PKClambda, PRKC iota, PRKC lambda/iota, PRKCI, Protein kinase C iota type

Brain, Liver or placenta.

Poids moléculaire: 68kDa

ID gène: 5584, 478199

UniProt: P41743

Pathways: Neurotrophin Signaling Pathway, Cell-Cell Junction Organization, Tube Formation