Leptin Receptor anticorps (AA 335-425)

N° du produit ABIN7864243

L’anticorps anti-Leptin Receptor Monoclonal Souris est utilisé pour la détection de Leptin Receptor dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour Leptin Receptor anticorps (AA 335-425) (ABIN7864243)

Antigène: Leptin Receptor (LEPR)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Leptin Receptor est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: LEPR-4545

Détail du produit anti-Leptin Receptor anticorps

Épitope: AA 335-425

Fonction: Leptin Receptor (LEPR) / Ob-R / CD295 Antibody

Specificité: Although there is substantial evidence that body weight is physiologically regulated, the molecular basis of obesity is unknown. Five single-gene mutations in mice that result in an obese phenotype have been identified. The first such recessive obesity mutation, the obese mutation (Ob), was identified in 1950. Mutation of Ob results in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. It has been postulated that the Ob gene product may function as a component of a signaling pathway in adipose tissue that functions to regulate body fat depot size. The cloning and sequence analysis of the mouse Ob gene and its human homolog has recently been described. Ob encodes an adipose tissue-specific mRNA with a highly conserved 167 amino acid open reading frame. The predicted amino acid sequence is 84 % identical between human and mouse and has the features of a secreted protein. A nonsense mutation in codon 105 has been found in the original congenic C57BL/6J Ob/Ob mouse strain. The Ob gene encodes the protein leptin. The leptin receptor, designated Ob-R, has been shown to be a single membrane-spanning receptor that most resembles the gp130 signal transducing component of the IL-6, G-CSF and LIF receptor. Ob-R mRNA is expressed in the choroid plexus and hypothalamus.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa335-425) of human LEPR protein (exact sequence is proprietary)

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur Leptin Receptor

Antigène: Leptin Receptor (LEPR)

Autre désignation: Leptin Receptor

Sujet:

Db, Fa, HuB219, LEP-R, LEPR, LEPRD, Leptin receptor, Leptin receptor fatty, Leptin receptor gene related protein, Leptin receptor precursor, OB R gene related protein (OB-RGRP), OB receptor (OBR / OB-R), obl

HepG2 or HeLa cells. Human heart|small intestine or fetal liver.

Poids moléculaire: 100kDa / 125kDa (short / long form)

ID gène: 3953

UniProt: P48357

Pathways: Signalistation JAK/STAT, AMPK Signaling, Feeding Behaviour