Recombinant Clusterin anticorps (AA 410-440)

N° du produit ABIN7860141

L’anticorps anti-Clusterin Monoclonal Souris est utilisé pour la détection de Clusterin dans des échantillons de Humain. Il a été validé pour WB et IHC.

Aperçu rapide pour Recombinant Clusterin anticorps (AA 410-440) (ABIN7860141)

Antigène: Clusterin (CLU)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Clusterin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: RCLU-9149

Détail du produit anti-Clusterin anticorps

Épitope: AA 410-440

Fonction: Recombinant Clusterin / Apolipoprotein J (APO-J) Antibody

Specificité: Clusterin, also designated complement lysis inhibitor (CLI), apolipoprotein J (APOJ), sulfated glycoprotein 2 (SGP2), SP40 and testosterone-repressed prostate message 2 (TRPM2), is a secretory, heterodimeric glycoprotein that influences immune regulation, cell adhesion, transformation, lipid transportation, tissue remodeling, membrane recycling and cell-cell interactions. Clusterin is synthesized as a 449 amino acid polypeptide that is post-translationally cleaved at an internal bond between Arg 227 and Ser 228. Two subunits, ± and ≤, are associated through disulfide bonds. The ≤ subunit (also called ApoJ±) corresponds to residues 23-227. The ± subunit (also called ApoJ≤) corresponds to residues 228-449. Overexpression of Clusterin appears to be more common in late stages of mammary tumor progression. Clusterin markedly influences ≤-Amyloid structure and neuritic toxicity in vivo and may influence Alzheimer s pathogenesis.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa410-440) of human CLU protein (exact sequence is proprietary)

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur Clusterin

Antigène: Clusterin (CLU)

Autre désignation: Clusterin

Sujet:

Aging associated protein 4, Apolipoprotein J, CLU1, CLU2, Clusterin alpha / beta chain, Complement associated protein SP40, Complement cytolysis inhibitor a chain, NA1/NA2, D14Ucla3, Dimeric acid glycoprotein, GP80, Ku70-binding protein 1 (KUB1), Sulfated glycoprotein 2 (SGP2), Testosterone repressed prostate message 2 (TPRM2B)

Human pancreas, Spleen|tonsil or cervix.

Poids moléculaire: 70kDa (precursor), 36-39kDa (é±), 34-36kDa (é≤)

ID gène: 1191, 436657

UniProt: P10909

Pathways: Apoptose, Negative Regulation of intrinsic apoptotic Signaling