MR1 anticorps (AA 50-250)

N° du produit ABIN7864929

L’anticorps anti-MR1 Monoclonal Souris est utilisé pour la détection de MR1 dans des échantillons de Humain. Il a été validé pour IHC.

Aperçu rapide pour MR1 anticorps (AA 50-250) (ABIN7864929)

Antigène: MR1 (Major Histocompatibility Complex, Class I-Related (MR1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MR1 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: MR1-7577

Détail du produit anti-MR1 anticorps

Épitope: AA 50-250

Fonction: MR1 / Major histocompatibility complex, class I-related Antibody

Specificité: MR1 (major histocompatibility complex, class I-related), also known as HLALS, is a 341 amino acid single-pass membrane protein that localizes to the endoplasmic reticulum, as well as to the extracellular side of the cell membrane, and contains one Ig-like C1-type domain. Expressed ubiquitously, MR1 exists as a heterodimer with b-2-Microglobulin and plays an important role in antigen presentation, specifically in the development and expansion of mucosalassociated invariant T cells (MAITs). MAITs are located in the gut and are involved in monitoring flora levels, as well as in conveying distress signals to other areas of the body, indicating a role for MR1 in proper digestion and immune system function. MR1 exists as four alternatively spliced isoforms and is encoded by a gene which maps to human chromosome 1.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (around aa50-250) of human MR1 protein (exact sequence is proprietary)

Isotype: IgG2, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Détails sur MR1

Antigène: MR1 (Major Histocompatibility Complex, Class I-Related (MR1))

Autre désignation: MR1

Sujet:

Class I histocompatibility antigen like protein, HLALS, Major histocompatibility complex class I like sequence, Major histocompatibility complex class I related isoform CRA a, MHC class I related gene protein, MHC class I related protein 1 isoform B, MR1B, MR1C

Human kidney|placenta or tonsil.

Poids moléculaire: 39kDa

ID gène: 3140, 13500

UniProt: Q95460

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints