Recombinant BRCA1 anticorps (N-Term)

N° du produit ABIN7860769

Cet anticorps anti-BRCA1 Monoclonal Lapin (Clone BRCA1-9797R) (ABIN7860769) détecte spécifiquement BRCA1 dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant BRCA1 anticorps (N-Term) (ABIN7860769)

Antigène: BRCA1 (Breast Cancer 1 (BRCA1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp BRCA1 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: BRCA1-9797R

Détail du produit anti-BRCA1 anticorps

Épitope: N-Term

Fonction: Recombinant BRCA1 (Breast Marker) Antibody

Specificité: This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.

Purification: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment (within the N-terminal 304 amino acids) of human BRCA1 protein

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Prepared in 10  mM PBS

Agent conservateur: Azide free

Stock: -20 °C,-80 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur BRCA1

Antigène: BRCA1 (Breast Cancer 1 (BRCA1))

Autre désignation: BRCA1

Sujet:

BRCA1, Breast and ovarian cancer susceptibility protein 1, Breast Cancer 1 Early Onset, Breast cancer type 1 susceptibility protein, BROVCA1, IRIS, PNCA4, PPP1R53, Protein phosphatase 1 regulatory subunit 53, PSCP, RING finger protein 53, RNF53

MCF7 or A431 cells. Human breast, ovarian or renal cell carcinoma.

Poids moléculaire: 220kDa

ID gène: 672, 194143

UniProt: P38398

Pathways: Cycle Cellulaire, Réparation de l'ADN, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus