Recombinant CD34 anticorps (AA 285-385)

N° du produit ABIN7864211

Cet anticorps anti-CD34 Monoclonal Lapin (Clone HPCA1-4393R) (ABIN7864211) détecte spécifiquement CD34 dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant CD34 anticorps (AA 285-385) (ABIN7864211)

Antigène: CD34

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp CD34 est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: HPCA1-4393R

Détail du produit anti-CD34 anticorps

Épitope: AA 285-385

Fonction: Recombinant CD34 (Hematopoietic Stem Cell & Endothelial Marker) Antibody

Specificité: CD34 (also named myeloid progenitor cell antigen) is a heavily glycosylated type I transmembrane protein. There are two forms of the CD34 protein, resulting from alternative splicing. The functions of CD34 is largely unknown, but recent evidence suggests a role for CD34 in cell adhesion and inhibition of hematopoiesis. It is suggested that CD34 is a signaling molecule involved in maintenance of a phenotypically plastic state in undifferentiated cells. CD34 is found in most endothelia, expressed on the luminal surface and membrane processes interdigitating between endothelial cells, but is absent from large veins and arteries. CD34 is furthermore expressed in fibroblast-like dendritic cells in, e.g., portal tracts of the liver, Peyer's patches, and in healing wounds. In smooth muscle cells, a variable CD34 staining is found. In tumor tissues, CD34 is detected in myeloid blasts in myelodysplastic syndrome and acute myeloid leukemia in most cases as well as lymphoblasts in most cases of B-acute lymphoblastic leukemia. Mature B- and T-cell lymphomas and leukemias are CD34 negative. The majority of vascular tumors, including hemangiosarcoma and Kaposi sarcoma are CD34positive. In a panel, CD34 staining is useful for the classification of myeloid and lymphoid neoplasms as well as spindle cell neoplasms (particularly identification of gastrointestinal stromal tumor and hemangiosarcoma).

Purification: 200ug/ml of recombinant MAb purified by Protein A/G.

Immunogène: Synthetic peptide corresponding to CD34 residues within aa285-385 of CD34 was used as an immunogen

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur CD34

Antigène: CD34

Autre désignation: CD34

Sujet:

Hematopoietic Progenitor Cell Antigen, HPCA1, Mucosialin

Jurkat or KG-1 cells. Human tonsil or angiosarcoma.

Poids moléculaire: 41kDa

ID gène: 947, 374990

UniProt: P28906