Integrin beta 3 anticorps

N° du produit ABIN7866126

Cet anticorps anti-Integrin beta 3 Monoclonal Souris (Clone 43-PL) (ABIN7866126) détecte spécifiquement Integrin beta 3 dans FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Integrin beta 3 anticorps (ABIN7866126)

Antigène: Integrin beta 3 (ITGB3)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Integrin beta 3 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: 43-PL

Détail du produit anti-Integrin beta 3 anticorps

Fonction: Mouse anti Human CD61

Attributs du produit: CD61 recognizes an Mr 110-kdalton ( kDa) protein, also known as gpIIIa, the common beta-subunit (integrin beta 3-chain) of the gpIIb/IIIa complex and the vitronectin receptor (VNR). The gpIIb/IIIa complex and the VNR are integrins, ie, a/b-heterodimeric glycoprotein complexes that are involved in cell adhesion. With the CD41 antigen (gpIIb or aIIb), the CD61 antigen forms the gpIIb/IIIa complex, which acts as a receptor for fibrinogen, von Willebrand factor (vWf), fibronectin and vitronectin on activated platelets. With the CD51 antigen (VNR a-chain or av), the CD61 antigen forms the VNR, which mediates activation-independent cell adhesion to vitronectin, vWf, fibrinogen, and thrombospondin. The CD61 antigen is found on all normal resting and activated platelets. The CD61 antigen is also found on endothelial cells, megakaryocytes, on some myeloid, erythroid and T-lymphoid leukemic cell lines.

Purification: Protein A/G Chromatography

Immunogène: Derived from the hybridization of mouse X63.Ag8.653 myeloma cells with spleen cells of BALB/c mice immunized with purified platelet membrane glycoproteins

Isotype: IgG1

Information d'application

Indications d'application: PBMC: Add10 μL of MAB/10^6 PBMC in 100 μL PBS. Mix gently and incubate for 15 minutes at 2° to 8 °C. Wash twice with PBS and analyze or fix with 0.5 % v/v of paraformaldehyde in PBS and analyze. WHOLE BLOOD: Add 10 μL of MAB/100 μL of whole blood. Mix gently and incubate for 15 minutes at room temperature (20 °C). Lyse the whole blood. Wash once with PBS and analyze or fix with 0.5 % v/v of paraformaldehyde in PBS and analyze. See instrument manufacturer's instructions for Lysed Whole Blood and Immunofluorescence analysis with a flow cytometer or microscope.

Restrictions: For Research Use only

Stockage

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur Integrin beta 3

Antigène: Integrin beta 3 (ITGB3)

Autre désignation: CD61

Sujet: CD61

UniProt: P05106

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex