Recombinant FLT3 anticorps (PE)

N° du produit ABIN7867268

Cet anticorps Lapin Chimeric détecte spécifiquement FLT3 dans FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Recombinant FLT3 anticorps (PE) (ABIN7867268)

Antigène: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Cet anticorp FLT3 est conjugé à/à la PE

Application: Flow Cytometry (FACS)

Clone: 19A5

Détail du produit anti-FLT3 anticorps (PE)

Fonction: PE-conjugated Anti-FLT3 antibody(19A5), IgG1 Chimeric mAb

Purification: Purified from cell culture supernatant by affinity chromatography

Isotype: IgG1

Information d'application

Indications d'application: Flow Cyt 1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid PBS with 0.05 %  Proclin300, 1 % BSA

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store at 2°C-8°C for 6 months

Date de péremption: 6 months

Détails sur FLT3

Antigène: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Autre désignation: FLT3

Sujet:

Synonyms: Flt-3,Flk-2,STK-1,CD135,FLK2,FLT-3

Target Background: Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2), STK-1(Stem cell tyrosine kinase 1), CD135. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

UniProt: P36888

Pathways: Signalisation RTK