PIN1 anticorps (AA 1-163)

N° du produit ABIN7868227

Cet anticorps anti-PIN1 Monoclonal Souris (Clone 5E5-) (ABIN7868227) détecte spécifiquement PIN1 dans WB, IF et FACS. L’anticorps est réactif avec des échantillons de Humain, Rat et Singe.

Aperçu rapide pour PIN1 anticorps (AA 1-163) (ABIN7868227)

Antigène: PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))

Reactivité: Humain, Rat, Singe

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PIN1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: 5E5-

Détail du produit anti-PIN1 anticorps

Épitope: AA 1-163

Fonction: PIN1 Antibody / Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Purification: Antigen affinity purified

Immunogène: E. coli-derived recombinant human protein (amino acids M1-E163) was used as the immunogen for the PIN1 antibody.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal dilution of the PIN1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the PIN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur PIN1

Antigène: PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))

Autre désignation: PIN1

Sujet: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, also called DOD, is an enzyme that in humans is encoded by the PIN1 gene. It is mapped to 19p13.2. The enzyme binds to a subset of proteins and thus plays a role in regulating protein function. Studies have shown that the deregulation of PIN1 may play a pivotal role in various diseases. Notably, the up-regulation of PIN1 may be implicated in certain cancers, and the down-regulation of Pin1 may be implicated in Alzheimer's disease. Inhibitors of PIN1 may have therapeutic implications for cancer and immune disorders. PIN1 activity regulates the outcome of proline-directed kinase (e.g. MAPK, CDK or GSK3) signalling and consequently regulates cell proliferation (in part through control of cyclin D1 levels and stability) and cell survival. PIN1 also has an essential role in maintaining cell proliferation and regulating cyclin D1 function.

UniProt: Q13526