CD3D anticorps (AA 1-171)

N° du produit ABIN7868243

Cet anticorps Souris Monoclonal détecte spécifiquement CD3D dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour CD3D anticorps (AA 1-171) (ABIN7868243)

Antigène: CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD3D est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CD3D-8898

Détail du produit anti-CD3D anticorps

Épitope: AA 1-171

Fonction: CD3 delta Antibody

Purification: Protein A/G affinity

Immunogène: A recombinant fragment (within amino acids 1-171) of human CD3D protein was used as the immunogen for the CD3 delta antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the CD3 delta antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the CD3 delta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur CD3D

Antigène: CD3D (CD3d Molecule, delta (CD3-TCR Complex) (CD3D))

Autre désignation: CD3 delta

Sujet: The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. Much of this signaling process can be attributed to a multisubunit complex of proteins that associates directly with the TCR. This complex has been designated CD3 (cluster of differentiation 3). It is composed of five invariant polypeptide chains that associate to form three dimers: a heterodimer of g and e chains (ge), a heterodimer of d and e chains (de) and a homodimer of two z chains (zz) or a heterodimer of z and h chains (zh). The z and h chains are encoded by the same gene but differ in their carboxyl-terminal ends due to an alternative splicing event. The g, e and d chains each contain a single copy of a conserved immunoreceptor tyrosine-based activation motif (ITAM). In contrast, the z chain contains three consecutive copies of the same motif. Phosphorylated ITAMs act as docking sites for protein kinases such as ZAP-70 and Syk and are also capable of regulating their kinase activity. The crystal structure of the ZAP-70 SH2 domains bound to the z chain ITAMs has been solved.

UniProt: P04234

Pathways: TCR Signaling, CXCR4-mediated Signaling Events