PYCARD anticorps (AA 1-195)

N° du produit ABIN7868349

L’anticorps anti-PYCARD Polyclonal Lapin est utilisé pour la détection de PYCARD dans des échantillons de Humain. Il a été validé pour WB, ELISA, IF, FACS et IHC (p).

Aperçu rapide pour PYCARD anticorps (AA 1-195) (ABIN7868349)

Antigène: PYCARD (PYD and CARD Domain Containing (PYCARD))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PYCARD est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-PYCARD anticorps

Épitope: AA 1-195

Fonction: TMS1 Antibody / Target of methylation-induced silencing 1 / PYCARD

Purification: Antigen affinity purified

Immunogène: E. coli-derived recombinant human protein (amino acids M1-S195) was used as the immunogen for the TMS1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the TMS1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the TMS1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur PYCARD

Antigène: PYCARD (PYD and CARD Domain Containing (PYCARD))

Autre désignation: TMS1

Sujet: PYCARD, often referred to as ASC (Apoptosis-associated speck-like protein containing a CARD) and Target of methylation-induced silencing 1 (TMS1), is a protein that in humans is encoded by the PYCARD gene. This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm, however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.

UniProt: Q9ULZ3

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation, Inflammasome