PARVG anticorps (AA 1-280)

N° du produit ABIN7869042

L’anticorps anti-PARVG Polyclonal Lapin est utilisé pour la détection de PARVG dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA et FACS.

Aperçu rapide pour PARVG anticorps (AA 1-280) (ABIN7869042)

Antigène: PARVG (Parvin, gamma (PARVG))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PARVG est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Détail du produit anti-PARVG anticorps

Épitope: AA 1-280

Fonction: PARVG Antibody / Gamma Parvin

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human PARVG recombinant protein (Position: M1-E280) was used as the immunogen for the PARVG antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the PARVG antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the PARVG antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur PARVG

Antigène: PARVG (Parvin, gamma (PARVG))

Autre désignation: PARVG

Sujet: PARVG antibody detects Gamma-parvin, a cytoskeletal adaptor protein that links integrins to actin filaments and regulates cell adhesion, motility, and signaling. The UniProt recommended name is Gamma-parvin (PARVG). This protein is a member of the parvin family of actin-binding proteins associated with focal adhesions and integrin-linked kinase (ILK) complexes.

Functionally, PARVG antibody identifies a 372-amino-acid cytoplasmic protein containing two calponin-homology (CH) domains that mediate actin binding and integrin interaction. PARVG participates in integrin-mediated adhesion signaling, influencing cell spreading, migration, and cytoskeletal dynamics. It contributes to mechanotransduction pathways in endothelial and immune cells.

The PARVG gene is located on chromosome 22q13.31 and is expressed in leukocytes, vascular smooth muscle cells, and skeletal muscle. PARVG regulates integrin activation and focal adhesion turnover, playing a key role in immune cell motility and vascular integrity.

Pathologically, altered PARVG expression has been linked to cancer cell migration, vascular remodeling, and inflammatory responses. Dysregulation of PARVG contributes to defective adhesion signaling and cytoskeletal organization. Research using PARVG antibody supports studies in integrin signaling, cytoskeletal remodeling, and vascular biology.

PARVG antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect cytoskeletal and adhesion-associated proteins. NSJ Bioreagents provides PARVG antibody reagents optimized for research in adhesion signaling, actin dynamics, and immune cell motility.

Structurally, Gamma-parvin contains CH1 and CH2 domains that facilitate actin binding and ILK-PINCH complex formation. This antibody aids in analyzing PARVG's function in integrin-linked cytoskeletal networks and adhesion regulation.

UniProt: Q9HBI0