CREB3 anticorps (AA 1-352)

N° du produit ABIN7869239

Cet anticorps Lapin Polyclonal détecte spécifiquement CREB3 dans WB, ELISA et IP. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour CREB3 anticorps (AA 1-352) (ABIN7869239)

Antigène: CREB3 (CAMP Responsive Element Binding Protein 3 (CREB3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CREB3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Détail du produit anti-CREB3 anticorps

Épitope: AA 1-352

Fonction: CREB3 Antibody / Cyclic AMP-responsive element-binding protein 3

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human CREB3 recombinant protein (Position: M1-K352) was used as the immunogen for the CREB3 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the CREB3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the CREB3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur CREB3

Antigène: CREB3 (CAMP Responsive Element Binding Protein 3 (CREB3))

Autre désignation: CREB3

Sujet: CREB3 antibody detects Cyclic AMP-responsive element-binding protein 3, a transcription factor involved in the unfolded protein response and endoplasmic reticulum (ER) stress regulation. The UniProt recommended name is Cyclic AMP-responsive element-binding protein 3 (CREB3). This ER membrane-bound transcription factor controls gene expression related to protein folding, trafficking, and secretion.

Functionally, CREB3 antibody identifies a 371-amino-acid protein anchored in the ER membrane with a cytoplasmic basic leucine zipper (bZIP) domain. Upon ER stress, the N-terminal transcriptional domain of CREB3 is cleaved and translocated to the nucleus, where it activates target genes involved in secretion and Golgi maintenance. CREB3 also regulates acute phase response genes and collagen biosynthesis.

The CREB3 gene is located on chromosome 9p13.3 and is highly expressed in secretory tissues such as liver, pancreas, and intestine. It plays a central role in adapting to increased secretory load and maintaining ER homeostasis under stress conditions.

Pathologically, dysregulation of CREB3 contributes to metabolic disorders, neurodegeneration, and cancer progression by disturbing ER stress response pathways. Overexpression can enhance tumor invasion by modulating extracellular matrix and stress-related signaling genes. Research using CREB3 antibody supports studies in transcriptional regulation, ER stress, and secretory pathway biology.

CREB3 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect transcription factors and stress response regulators. NSJ Bioreagents provides CREB3 antibody reagents optimized for research in cellular homeostasis, transcription, and disease adaptation.

Structurally, Cyclic AMP-responsive element-binding protein 3 contains a bZIP domain for DNA binding and dimerization, along with a luminal stress-sensing region. This antibody enables investigation of CREB3's role in ER stress signaling and transcriptional control.

UniProt: O43889

Pathways: Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Maintenance of Protein Location, Unfolded Protein Response