Phospholamban anticorps (AA 1-36)

N° du produit ABIN7869249

L’anticorps anti-Phospholamban Polyclonal Lapin est utilisé pour la détection de Phospholamban dans des échantillons de Humain, Rat et Souris. Il a été validé pour WB, ELISA et IHC (p).

Aperçu rapide pour Phospholamban anticorps (AA 1-36) (ABIN7869249)

Antigène: Phospholamban (PLN)

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Phospholamban est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-Phospholamban anticorps

Épitope: AA 1-36

Fonction: PLB Antibody / Phospholamban / PLN

Purification: Antigen affinity purified

Immunogène: Recombinant human protein (amino acids M1-C36) was used as the immunogen for the PLB antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the PLB antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the PLB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Phospholamban

Antigène: Phospholamban (PLN)

Autre désignation: PLB

Sujet: Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2+ pump in cardiac muscle and skeletal muscle cells. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. Phospholamban is also expressed in slow-twitch skeletal muscle and some smooth muscle cells. It is observed that human ventricle and quadriceps displayed high levels of phospholamban transcripts and proteins, with markedly lower expression observed in smooth muscles, while the right atrium also expressed low levels of phospholamban. The structure of the human phospholamban gene closely resembles that reported for chicken, rabbit, rat, and mouse. Comparison of the human to other mammalian phospholamban genes indicated a marked conservation of sequence for at least 217 bp upstream of the transcription start site.

UniProt: P26678

Pathways: Negative Regulation of Transporter Activity