VANGL2 anticorps (AA 1-489)

N° du produit ABIN7869408

L’anticorps anti-VANGL2 Polyclonal Lapin est utilisé pour la détection de VANGL2 dans des échantillons de Poisson zèbre (Danio rerio). Il a été validé pour WB et IHC (p).

Aperçu rapide pour VANGL2 anticorps (AA 1-489) (ABIN7869408)

Antigène: VANGL2 (Vang-Like 2 (VANGL2))

Reactivité: Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VANGL2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-VANGL2 anticorps

Épitope: AA 1-489

Fonction: Zebrafish Vangl2 Antibody / Vang-like protein 2

Purification: Antigen affinity chromatography

Immunogène: E. coli-derived zebrafish Vangl2 recombinant protein (amino acids M1-D489) was used as the immunogen for the Zebrafish Vangl2 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal dilution of the Zebrafish Vangl2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Zebrafish Vangl2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur VANGL2

Antigène: VANGL2 (Vang-Like 2 (VANGL2))

Autre désignation: Vangl2

Sujet: Van Gogh-like protein 2 (Vangl2) is a core component of the planar cell polarity (PCP) pathway, a non-canonical Wnt signaling pathway that regulates the orientation and coordinated movement of cells within the plane of a tissue. In zebrafish (Danio rerio), Vangl2 plays a vital role in embryonic morphogenesis, particularly in convergent extension movements during gastrulation, which are essential for body axis elongation.

Zebrafish vangl2 is expressed early in development and is critical for establishing tissue polarity and directional cell migration. Mutations in vangl2-such as the well-studied trilobite mutant-lead to severe defects in neural tube formation, somite patterning, and organ positioning, making it a key model for understanding PCP signaling in vertebrates.

Given its high conservation and pivotal role in developmental processes, zebrafish Vangl2 is widely used to study cell polarity, tissue architecture, and congenital disorders such as neural tube defects. It also provides valuable insights into cytoskeletal organization, cell-cell communication, and signal integration during vertebrate development.

UniProt: Q8UVJ6

Pathways: Signalisation WNT, Stem Cell Maintenance, Tube Formation, Asymmetric Protein Localization