INSIG1 anticorps (AA 1-87)

N° du produit ABIN7869598

Cet anticorps anti-INSIG1 Polyclonal Lapin (ABIN7869598) détecte spécifiquement INSIG1 dans WB, ELISA, IF, FACS et IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour INSIG1 anticorps (AA 1-87) (ABIN7869598)

Antigène: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp INSIG1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-INSIG1 anticorps

Épitope: AA 1-87

Fonction: Insulin-induced gene 1 Antibody / INSIG1

Purification: Antigen affinity purified

Immunogène: An E.coli-derived human recombinant protein (amino acids M1-R87) was used as the immunogen for the Insulin-induced gene 1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Insulin-induced gene 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Insulin-induced gene 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur INSIG1

Antigène: INSIG1 (Insulin Induced Gene 1 (INSIG1))

Autre désignation: Insulin-induced gene 1

Sujet: Insulin induced gene 1, also known as INSIG1, is a protein which in humans is encoded by the INSIG1 gene. This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants.

UniProt: O15503

Pathways: ER-Nucleus Signaling