Aurora A anticorps (AA 1-97)

N° du produit ABIN7869653

Cet anticorps Lapin Polyclonal détecte spécifiquement Aurora A dans WB, ELISA, IF, IHC (p) et FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Aurora A anticorps (AA 1-97) (ABIN7869653)

Antigène: Aurora A (AURKA) (Aurora Kinase A (AURKA))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Aurora A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Détail du produit anti-Aurora A anticorps

Épitope: AA 1-97

Fonction: Aurora A Antibody / AURKA

Purification: Antigen affinity purified

Immunogène: Recombinant human protein (amino acids M1-K97) was used as the immunogen for the Aurora A antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Aurora A antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Aurora A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Aurora A

Antigène: Aurora A (AURKA) (Aurora Kinase A (AURKA))

Autre désignation: Aurora A

Sujet: AURKA (aurora kinase A), also called ARK1, AurA, AIK, AURORA2, BTAK, PPP1R47, STK7, STK15 and STK6 is a mitotic centrosomal protein kinase. The main role of AURKA in tumor development is in controlling chromosome segregation during mitosis. Aurora A is a member of a family of mitotic serine/threonine kinases. Cell cycle and Northern blot analyses showed that peak expression of AURKA occurs during the G2/M phase and then decreases. By fluorescence in situ hybridization, AURKA gene is represented by 2 signals in chromosome bands 20q13.2-q13.3 and 1q41-q42. The AURKA gene is overexpressed in many human cancers. Ectopic overexpression of Aurora kinase A in mammalian cells induces centrosome amplification, chromosome instability, and oncogenic transformation, a phenotype characteristic of loss-of-function mutations of p53. Depletion of Ajuba prevented activation of AURKA at centrosomes in late G2 phase and inhibited mitotic entry. Activation of AURKA was independently sufficient to induce rapid ciliary resorption, and AURKA acted in this process through phosphorylation of HDAC6, leading to HDAC6-dependent tubulin deacetylation and destabilization of the ciliary axoneme. Small molecule inhibitors of AURKA and HDAC6 reduced regulated disassembly of cilia.

UniProt: O14965

Pathways: Cycle Cellulaire, Asymmetric Protein Localization