VCP anticorps (AA 10-512)

N° du produit ABIN7869710

Cet anticorps Lapin Polyclonal détecte spécifiquement VCP dans WB et IHC (p). Il présente une réactivité avec des échantillons de Poisson zèbre (Danio rerio).

Aperçu rapide pour VCP anticorps (AA 10-512) (ABIN7869710)

Antigène: VCP (Valosin Containing Protein (VCP))

Reactivité: Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VCP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-VCP anticorps

Épitope: AA 10-512

Fonction: Zebrafish Cdc48 Antibody / Valosin-containing protein / Vcp

Purification: Antigen affinity chromatography

Immunogène: E. coli-derived zebrafish Cdc48 recombinant protein (amino acids D10-K512) was used as the immunogen for the Zebrafish Cdc48 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Optimal dilution of the Zebrafish Cdc48 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Zebrafish Cdc48 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur VCP

Antigène: VCP (Valosin Containing Protein (VCP))

Autre désignation: Cdc48

Sujet: Zebrafish Cdc48, also known as cell division cycle 48, is a crucial ATPase that is involved in various cellular processes including protein degradation, cell cycle regulation, and membrane dynamics. Cdc48 is part of the AAA+ ATPase family and functions as a part of the 26S proteasome pathway, where it helps to extract polyubiquitinated substrates from the proteasome or other cellular compartments for degradation. Additionally, Cdc48 plays a role in endoplasmic reticulum associated degradation (ERAD), maintaining cellular homeostasis by ensuring the removal of misfolded proteins.

Zebrafish Cdc48 is an ortholog of the human CDC48 protein, also known as p97. It shares significant sequence and functional conservation with its human counterpart, ensuring that it performs similar roles in regulating protein turnover, signaling pathways, and cell cycle progression. Like human p97, zebrafish Cdc48 is essential for the regulation of processes such as DNA repair, organelle biogenesis, and apoptosis, and its dysfunction can result in various diseases, including neurodegenerative disorders and certain cancers.

The use of a Zebrafish Cdc48 antibody is an invaluable tool for studying protein quality control mechanisms and their role in cellular stress responses. Such antibodies are essential for applications including western blot, immunohistochemistry, immunofluorescence, and ELISA. With a Zebrafish Cdc48 antibody, researchers can analyze Cdc48 expression in different tissues, study its involvement in proteostasis, and investigate how alterations in its function impact development and disease.

Currently, no isoforms of zebrafish Cdc48 have been documented, but its essential role in cellular maintenance and its conservation across species make it an important target for research. A high-quality Zebrafish Cdc48 antibody provides essential insights into cellular stress mechanisms and the regulation of the ubiquitin-proteasome system in zebrafish models.

UniProt: Q7ZU99

Pathways: ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Ubiquitin Proteasome Pathway