CTNND1 anticorps (AA 100-300)

N° du produit ABIN7869818

Cet anticorps Souris Monoclonal détecte spécifiquement CTNND1 dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour CTNND1 anticorps (AA 100-300) (ABIN7869818)

Antigène: CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CTNND1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: CTNND1-4207

Détail du produit anti-CTNND1 anticorps

Épitope: AA 100-300

Fonction: Catenin delta 1 Antibody / CTNND1 / p120 Catenin (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 100-300 was used as the immunogen for the Catenin delta 1 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the Catenin delta 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the Catenin delta 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur CTNND1

Antigène: CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))

Autre désignation: Catenin delta 1

Sujet: Alpha-catenin and beta-catenin bind to the intracellular domain of E-cadherin while p120 catenin binds E-cadherin at a juxta-membrane site. The complex stabilizes tight junctions. In the cell, p120 catenin localized to the E-cadherin/catenins cell adhesion complex, directly associates with cytoplasmic C-terminus of E-cadherin and may similarly interact with other cadherins. p120 is a proliferation-associated nucleolar protein found in most human malignant tumors, but not in resting normal cells. In colorectal cancer the altered localization of p120 catenin corresponds with loss of cytoplasmic localization of E-cadherin. Studies have shown accurate categorization of ductal vs. lobular neoplasia in the breast was achieved with p120 staining. p120 expression further clarifies the separation of low-grade ductal carcinoma in situ from lobular neoplasia. Studies also have shown that altered expression of p120 catenin antibody predicts poor outcome in invasive breast cancer.

UniProt: O60716

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling