MAP1B anticorps (AA 102-1849)

N° du produit ABIN7869909

L’anticorps anti-MAP1B Polyclonal Lapin est utilisé pour la détection de MAP1B dans des échantillons de Humain, Souris et Rat. Il a été validé pour IHC, WB, ELISA, FACS et IF.

Aperçu rapide pour MAP1B anticorps (AA 102-1849) (ABIN7869909)

Antigène: MAP1B (Microtubule-Associated Protein 1B (MAP1B))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP1B est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF)

Détail du produit anti-MAP1B anticorps

Épitope: AA 102-1849

Fonction: MAP1B Antibody / Microtubule-associated protein 1B

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human MAP1B recombinant protein (Position: H102-R1849) was used as the immunogen for the MAP1B antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the MAP1B antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the MAP1B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur MAP1B

Antigène: MAP1B (Microtubule-Associated Protein 1B (MAP1B))

Autre désignation: MAP1B

Sujet: MAP1B antibody detects Microtubule-associated protein 1B, a neuronal cytoskeletal protein that regulates microtubule stability, axon guidance, and neuronal differentiation. The UniProt recommended name is Microtubule-associated protein 1B (MAP1B). This large microtubule-binding protein plays an essential role during nervous system development by stabilizing and organizing microtubule networks within axons and dendrites.

Functionally, MAP1B antibody identifies a precursor protein of approximately 2,460 amino acids that is proteolytically cleaved into heavy and light chains. These subunits assemble with microtubules and actin filaments, promoting cytoskeletal crosslinking. MAP1B is enriched in developing neurons, where it modulates growth cone dynamics and neurite outgrowth, influencing axonal pathfinding and regeneration.

The MAP1B gene is located on chromosome 5q13.2 and is highly expressed in the central and peripheral nervous systems. MAP1B associates with other neuronal cytoskeletal proteins, such as tau and MAP2, to regulate polymerization and microtubule stability. Phosphorylation of MAP1B by kinases including GSK3 and CDK5 modulates its binding affinity and spatial localization, fine-tuning neuronal polarity and maturation.

Pathologically, aberrant MAP1B expression or phosphorylation is associated with neurodevelopmental and neurodegenerative diseases, including Alzheimeri 1/2s and Parkinsoni 1/2s disease. In tumor cells, MAP1B re-expression correlates with altered cytoskeletal organization and invasiveness. Research using MAP1B antibody supports studies in axonal transport, cytoskeletal remodeling, and neuronal repair mechanisms.

MAP1B antibody is validated for western blotting, immunohistochemistry, and immunofluorescence to detect neuronal microtubule-associated proteins. NSJ Bioreagents offers MAP1B antibody reagents optimized for neurobiology, cytoskeletal, and developmental research applications.

Structurally, Microtubule-associated protein 1B contains multiple microtubule-binding domains and an actin-binding region, facilitating cytoskeletal integration. Its dynamic phosphorylation pattern determines its localization and activity during neuron growth and regeneration. This antibody provides a reliable tool to examine MAP1B's regulatory functions in cytoskeletal organization and axonal development.

UniProt: P46821

Pathways: Dynamique des Microtubules, Regulation of Cell Size