TCTN1 anticorps (AA 118-470)

N° du produit ABIN7870264

Cet anticorps anti-TCTN1 Polyclonal Lapin (ABIN7870264) détecte spécifiquement TCTN1 dans WB, ELISA, IHC et FACS. L’anticorps est réactif avec des échantillons de Rat, Humain et Souris.

Aperçu rapide pour TCTN1 anticorps (AA 118-470) (ABIN7870264)

Antigène: TCTN1 (Tectonic Family Member 1 (TCTN1))

Reactivité: Rat, Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TCTN1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Détail du produit anti-TCTN1 anticorps

Épitope: AA 118-470

Fonction: TCTN1 Antibody / Tectonic 1

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human TCTN1 recombinant protein (Position: Q118-Y470) was used as the immunogen for the TCTN1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the TCTN1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the TCTN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur TCTN1

Antigène: TCTN1 (Tectonic Family Member 1 (TCTN1))

Autre désignation: TCTN1

Sujet: TCTN1 antibody detects Tectonic-1, a membrane-associated protein essential for ciliogenesis and Hedgehog signaling. The UniProt recommended name is Tectonic-1 (TCTN1). This protein localizes to the ciliary transition zone, where it participates in the formation and maintenance of the primary cilium, a sensory organelle crucial for signal transduction during embryonic development and tissue patterning.

Functionally, TCTN1 antibody identifies a 765-amino-acid protein that interacts with other tectonic complex components such as TCTN2, TCTN3, and MKS1. TCTN1 regulates protein trafficking into the cilium and ensures the proper localization of signaling receptors, including those of the Hedgehog pathway. It is indispensable for normal morphogenesis and neural tube patterning.

The TCTN1 gene is located on chromosome 12q24.11 and is expressed in ciliated cells throughout various tissues, including brain, kidney, and retina. Its activity maintains ciliary structure and mediates signal coordination during development and organogenesis.

Pathologically, mutations in TCTN1 lead to ciliopathies such as Joubert and Meckel-Gruber syndromes, which are characterized by developmental defects in the brain, kidneys, and eyes. Dysfunction of TCTN1 disrupts ciliary signaling, resulting in structural malformations and impaired embryonic patterning. Research using TCTN1 antibody supports studies in ciliary biology, developmental signaling, and ciliopathy mechanisms.

TCTN1 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect ciliary transition zone proteins. NSJ Bioreagents provides TCTN1 antibody reagents optimized for developmental biology, signal transduction, and structural cell biology research.

Structurally, Tectonic-1 contains multiple coiled-coil regions and a C-terminal transmembrane domain that anchor it to the ciliary membrane. This antibody enables investigation of TCTN1's function in ciliogenesis and Hedgehog pathway regulation.

UniProt: Q2MV58

Pathways: Tube Formation