ATG16L1 anticorps (AA 161-190)

N° du produit ABIN7871107

Cet anticorps anti-ATG16L1 Polyclonal Lapin (ABIN7871107) détecte spécifiquement ATG16L1 dans WB, IF et IHC (p). L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour ATG16L1 anticorps (AA 161-190) (ABIN7871107)

Antigène: ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATG16L1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-ATG16L1 anticorps

Épitope: AA 161-190

Fonction: ATG16L Antibody

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 161-190 from the human protein were used as the immunogen for the ATG16L1 Antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the ATG16L1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the ATG16L1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur ATG16L1

Antigène: ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))

Autre désignation: ATG16L

Sujet: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The APG12-APG5-APG16L complex is esential for the elongation of autophagic isolation membranes. This complex initially associates in uniform distribution with small vesicle membranes. During membrane elongation, the complex partitions, with a great concentration building on the outer side of the isolation membrane. Upon completion of the formation of the autophagosome, the APG12-APG5-APG16L dissociates from the membrane.

UniProt: Q676U5

Pathways: Autophagy