TGF-beta anticorps (AA 200-390)

N° du produit ABIN7871991

L’anticorps anti-TGF-beta Monoclonal Souris est utilisé pour la détection de TGF-beta dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour TGF-beta anticorps (AA 200-390) (ABIN7871991)

Antigène: TGF-beta (TGFb)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TGF-beta est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TGFB-7240

Détail du produit anti-TGF-beta anticorps

Épitope: AA 200-390

Fonction: TGF beta Antibody / TGFB

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 200-390) from the human TGFB1 was used as the immunogen for the TGF beta antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the TGF beta antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the TGF beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur TGF-beta

Antigène: TGF-beta (TGFb)

Autre désignation: TGF beta

Sujet: This mAb recognizes TGF beta 1, 2 and 3. Three TGF betas have been identified in mammals. TGF beta 1, TGF beta 2 and TGF beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGF beta requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGF beta 3 protein has approximately 80 % identity to the mature region of both TGF beta 1 and TGF beta 2. However, the NH2 terminals or precursor regions of their molecules share only 27 % sequence identity. TGF beta s inhibits the growth of epithelial cells and stimulate the growth of mesenchymal cells.

UniProt: P01137

Pathways: EGFR Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus