DERL1 anticorps (AA 224-251)

N° du produit ABIN7872381

L’anticorps anti-DERL1 Polyclonal Lapin est utilisé pour la détection de DERL1 dans des échantillons de Humain et Souris. Il a été validé pour WB, IHC (p) et FACS.

Aperçu rapide pour DERL1 anticorps (AA 224-251) (ABIN7872381)

Antigène: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DERL1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Détail du produit anti-DERL1 anticorps

Épitope: AA 224-251

Fonction: Derlin 1 Antibody / DERL1

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 224-251 from the human protein was used as the immunogen for the Derlin 1 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the Derlin 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Derlin 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur DERL1

Antigène: DERL1 (Der1-Like Domain Family, Member 1 (DERL1))

Autre désignation: Derlin 1

Sujet: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. DERL1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. It may mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.

UniProt: Q9BUN8

Pathways: ER-Nucleus Signaling