NCOA2 anticorps (AA 297-1071)

N° du produit ABIN7873467

L’anticorps anti-NCOA2 Polyclonal Lapin est utilisé pour la détection de NCOA2 dans des échantillons de Humain. Il a été validé pour WB, IHC, ELISA, IF, ICC et FACS.

Aperçu rapide pour NCOA2 anticorps (AA 297-1071) (ABIN7873467)

Antigène: NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NCOA2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Détail du produit anti-NCOA2 anticorps

Épitope: AA 297-1071

Fonction: NCOA2 Antibody / Nuclear receptor coactivator 2

Purification: Immunogen affinity purified

Immunogène: E.coli-derived human NCOA2 recombinant protein (Position: E297-E1071) was used as the immunogen for the NCOA2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the NCOA2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the NCOA2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur NCOA2

Antigène: NCOA2 (Nuclear Receptor Coactivator 2 (NCOA2))

Autre désignation: NCOA2

Sujet: NCOA2 antibody detects Nuclear receptor coactivator 2, encoded by the NCOA2 gene. Nuclear receptor coactivator 2 is a transcriptional coactivator that interacts with nuclear hormone receptors and enhances their transcriptional activity. NCOA2 antibody provides researchers with a valuable reagent for studying gene regulation, endocrine signaling, and cancer biology.

Nuclear receptor coactivator 2, also called SRC2 or GRIP1, belongs to the p160 family of coactivators. Research using NCOA2 antibody has shown that it interacts with estrogen receptor, glucocorticoid receptor, thyroid hormone receptor, and peroxisome proliferator-activated receptor. By recruiting histone acetyltransferases and chromatin remodeling complexes, NCOA2 promotes transcriptional activation in response to hormones and ligands.

Studies with NCOA2 antibody have revealed that it is widely expressed in endocrine tissues, brain, and muscle. Its ability to act as a transcriptional scaffold allows integration of multiple signaling inputs, fine-tuning transcriptional responses. This makes NCOA2 central to metabolism, reproduction, and development.

Dysregulation of NCOA2 has been linked to endocrine disorders and cancer. Research using NCOA2 antibody has shown that chromosomal translocations involving NCOA2 occur in acute lymphoblastic leukemia and mesenchymal tumors. Overexpression has also been observed in prostate and breast cancers, where NCOA2 enhances oncogenic signaling. These findings underscore its importance as a biomarker and potential therapeutic target.

NCOA2 antibody is widely used in chromatin immunoprecipitation, western blotting, and immunohistochemistry. Chromatin immunoprecipitation identifies nuclear receptor binding sites, western blotting quantifies coactivator expression, and immunohistochemistry demonstrates nuclear localization in hormone-responsive tissues. These methods make NCOA2 antibody essential for transcription and cancer research.

By providing validated NCOA2 antibody reagents, NSJ Bioreagents supports studies into transcriptional regulation, hormone signaling, and oncogenesis. Detection of Nuclear receptor coactivator 2 provides researchers with insight into how nuclear coactivators integrate signaling pathways and control gene expression.

UniProt: Q15596

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Regulation of Lipid Metabolism by PPARalpha, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling