Leptin Receptor anticorps (AA 335-425)

N° du produit ABIN7874039

Cet anticorps Souris Monoclonal détecte spécifiquement Leptin Receptor dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Leptin Receptor anticorps (AA 335-425) (ABIN7874039)

Antigène: Leptin Receptor (LEPR)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Leptin Receptor est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: LEPR-4304

Détail du produit anti-Leptin Receptor anticorps

Épitope: AA 335-425

Fonction: LEPR Antibody / Leptin Receptor / Ob-R (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: A portion of amino acids 335-425 was used as the immunogen for the LEPR antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the LEPR antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the LEPR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Leptin Receptor

Antigène: Leptin Receptor (LEPR)

Autre désignation: LEPR

Sujet: Although there is substantial evidence that body weight is physiologically regulated, the molecular basis of obesity is unknown. Five single-gene mutations in mice that result in an obese phenotype have been identified. The first such recessive obesity mutation, the obese mutation (Ob), was identified in 1950. Mutation of Ob results in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. It has been postulated that the Ob gene product may function as a component of a signaling pathway in adipose tissue that functions to regulate body fat depot size. The cloning and sequence analysis of the mouse Ob gene and its human homolog has recently been described. Ob encodes an adipose tissue-specific mRNA with a highly conserved 167 amino acid open reading frame. The predicted amino acid sequence is 84 % identical between human and mouse and has the features of a secreted protein. A nonsense mutation in codon 105 has been found in the original congenic C57BL/6J Ob/Ob mouse strain. The Ob gene encodes the protein leptin. The leptin receptor, designated Ob-R, has been shown to be a single membrane-spanning receptor that most resembles the gp130 signal transducing component of the IL-6, G-CSF and LIF receptor. Ob-R mRNA is expressed in the choroid plexus and hypothalamus.

UniProt: P48357

Pathways: Signalistation JAK/STAT, AMPK Signaling, Feeding Behaviour