MAG anticorps (AA 34-605)

N° du produit ABIN7874086

Cet anticorps anti-MAG Monoclonal Souris (Clone 2G11) (ABIN7874086) détecte spécifiquement MAG dans WB, FACS, IF et IHC (p). L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour MAG anticorps (AA 34-605) (ABIN7874086)

Antigène: MAG (Myelin Associated Glycoprotein (MAG))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MAG est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 2G11

Détail du produit anti-MAG anticorps

Épitope: AA 34-605

Fonction: Siglec-4a Antibody / MAG / Myelin-associated glycoprotein

Purification: Affinity purified

Immunogène: A human recombinant partial protein (amino acids E34-R605) was used as the immunogen for the Siglec-4a antibody.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal dilution of the Siglec-4a antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Siglec-4a antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur MAG

Antigène: MAG (Myelin Associated Glycoprotein (MAG))

Autre désignation: Siglec-4a

Sujet: MAG (Myelin-associated glycoprotein), also known as Siglec-4a, is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR. It is though to be involved in the process of myelination. MAG is a sialic acid-binding SIGLEC protein and is a functional ligand for the NOGO receptor.The MAG gene is mapped on 19q13.12. Cleavage of GPI-linked proteins from axons protects growth cones from MAG-induced collapse, and dominant-negative NgR eliminates MAG inhibition of neurite outgrowth. MAG-resistant embryonic neurons were rendered MAG-sensitive by expression of NgR. MAG binds specifically to an NgR-expressing cell line in a GPI-dependent and sialic acid-independent manner. Experiments blocking NgR from interacting with MAG prevented inhibition of neurite outgrowth by MAG. In cultured human embryonic kidney(HEK) cells expressing the NOGO receptor, p75(NTR) was required for MAG-induced intracellular calcium elevation.

UniProt: P20916

Pathways: Neurotrophin Signaling Pathway