MMP12 anticorps (AA 391-420)

N° du produit ABIN7874614

Cet anticorps anti-MMP12 Polyclonal Lapin (ABIN7874614) détecte spécifiquement MMP12 dans WB, IHC (p) et IF. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour MMP12 anticorps (AA 391-420) (ABIN7874614)

Antigène: MMP12 (Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MMP12 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Détail du produit anti-MMP12 anticorps

Épitope: AA 391-420

Fonction: MMP12 Antibody

Purification: Antigen affinity purified

Immunogène: A portion of amino acids 391-420 from the human protein were used as the immunogen for the MMP12 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: The stated application concentrations are suggested starting points. Titration of the MMP12 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the MMP12 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur MMP12

Antigène: MMP12 (Matrix Metallopeptidase 12 (Macrophage Elastase) (MMP12))

Autre désignation: MMP12

Sujet: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP12 may be involved in tissue injury and remodeling. This protein has significant elastolytic activity. MMP12 can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, wtih small hydrophobic residues (prefereably alanine) occupying P3. The protein is found in alveolar macrophages but not in peripheral blood monocytes. MMP12 can be induced by exposure to lypopolysaccharide, and is inhibited by dexamethasone.

UniProt: P39900