Recombinant SMAD4 anticorps (AA 400-552)

N° du produit ABIN7874727

L’anticorps anti-SMAD4 Monoclonal Lapin est utilisé pour la détection de SMAD4 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour Recombinant SMAD4 anticorps (AA 400-552) (ABIN7874727)

Antigène: SMAD4 (SMAD Family Member 4 (SMAD4))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp SMAD4 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SMAD4-7905R

Détail du produit anti-SMAD4 anticorps

Épitope: AA 400-552

Fonction: SMAD4 Antibody

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein sequence (within amino acids 400-552) from the human protein was used as the immunogen for the SMAD4 antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the SMAD4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Aliquot the SMAD4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur SMAD4

Antigène: SMAD4 (SMAD Family Member 4 (SMAD4))

Autre désignation: SMAD4

Sujet: SMAD4 is implicated as a tumor suppressor since it is inactivated in more than half of pancreatic carcinomas and to a lesser extent in a variety of other cancers. The lack of SMAD4 expression is present in approximately 80 % of cases of pancreatic adenocarcinoma, but rarely in endometrial (0 %), colorectal (0 %), ovarian (3 %), lung (0 %), breast (2 %) adenocarcinomas, and malignant melanoma (4 %). SMAD4is an important marker for confirming a diagnosis of pancreatic adenocarcinoma.

UniProt: Q13485

Pathways: Cycle Cellulaire, Chromatin Binding, Autophagy