Filamin A anticorps (AA 451-638)

N° du produit ABIN7875095

Cet anticorps Souris Monoclonal détecte spécifiquement Filamin A dans WB, IF et IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Filamin A anticorps (AA 451-638) (ABIN7875095)

Antigène: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Filamin A est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 3F8

Détail du produit anti-Filamin A anticorps

Épitope: AA 451-638

Fonction: FLNA Antibody / Filamin A

Purification: Affinity purified

Immunogène: A human recombinant partial protein (amino acids E451-Q638) was used as the immunogen for the FLNA antibody.

Isotype: IgG1

Information d'application

Indications d'application: Optimal dilution of the FLNA antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the FLNA antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Filamin A

Antigène: Filamin A (FLNA) (Filamin A, alpha (FLNA))

Autre désignation: FLNA

Sujet: Filamin A, alpha (FLNA) is a protein that in humans is encoded by the FLNA gene. It is mapped to Xq28. The protein encoded by this gene is an actin-binding protein that crosslinks actin filaments and links actin filaments to membrane glycoproteins. The encoded protein is involved in remodeling the cytoskeleton to effect changes in cell shape and migration. This protein interacts with integrins, transmembrane receptor complexes, and second messengers. Defects in this gene are a cause of several syndromes, including periventricular nodular heterotopias (PVNH1, PVNH4), otopalatodigital syndromes (OPD1, OPD2), frontometaphyseal dysplasia (FMD), Melnick-Needles syndrome (MNS), and X-linked congenital idiopathic intestinal pseudoobstruction (CIIPX). Two transcript variants encoding different isoforms have been found for this gene.

UniProt: P21333

Pathways: TCR Signaling, Maintenance of Protein Location